Sunday September 13, 2009

Q: What is the dosing adjustment of Primaxin (Imipenem/Cilastatin) in Hemdialysis and CVVHD (CRRT)?


Answer: Primaxin (Imipenem/Cilastatin) need to be adjusted in Hemodialysis and CVVHD (CRRT) patients.

DOSING IN HEMODIALYSIS:
250 mg IV q12h with 250 mg post dialysis on dialysis day.

DOSING IN HEMOFILTRATION:
1. CVVHD with dialysis flow rate less than 1.5L/hr: 500 mg IV q12h;
2. CVVHD with dialysis flow rate 2L/hr: 500 mg IV q 8h.